547 jobs found in worcester

About AbbVie AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn . The QA CAPA Analyst position supports the activities and initiatives of the Quality Manager to implement and manage the Quality System. This includes support on: exception reports, policy &procedure, program management, internal/external audit, and metrics and trend analysis and reporting. Responsibilities Review and approve, as appropriate, CAPA, Change Control and Risk Management related documentation....

Role Summary: The Sr. Automation Engineer will have responsibility for maintaining regulatory aspects of manufacturing networks, control and monitoring systems, and data collection used throughout AbbVie Bioresearch Center’s biologics manufacturing facility. The Sr. Automation Engineer shall possess the skill set necessary to ensure the success of automation and engineering projects at the site. Responsibilities & Essential Functions include: Responsible for design, development, and testing of process automation systems such as Foxboro I/A DCS, Rockwell PLCs, etc. Responsible for providing support to manufacturing data historian and analytics systems such as OSISoft PI, Smart Factory Rx, etc. Apply engineering principles and technical expertise in supporting project execution and operational support activities. Provide automation improvements based on cGMP’s related to the operation, validation, and maintenance of manufacturing related computer...

Shipping finished materials. Maintaining inventory levels. Sampling of in process and raw materials. Running glass washer / autoclave. Buffer / media preparation. Equipment preparation (CIP / SIP). Cell culture (from vial thaw to production scale). Column chromatography. Tangential flow filtration.

Transfers methods into Production instructions to allow for successful performance of scheduled campaigns. Schedules work tasks, without assistance, to support project and campaign timelines. Drafts broad scope and complexity documents. Circulates the documents to reviewers and without assistance responds to comments and questions. Manages document review and approval to meet project timelines. Directs changeover activities with limited assistance. Exercises judgment within broadly defined practices and policies in selecting methods, techniques, and evaluation criteria for obtaining results. Tracks ongoing problems and gathers information for analysis. Uses analysis to develop solutions to broad-level problems. Presents potential solutions to management and senior personnel, and with limited assistance creates an implementation plan. Evaluates data for trends, which may impact other systems, projects, or areas. Applies knowledge, experience, and technical skills to...

AbbVie Bioresearch Center (ABC) is looking for Manufacturing Technicians III/ IV to join their team in Worcester, MA. The Manufacturing Technician performs functions associated with cGMP manufacturing operations within the biologics production facility, including working with engineers in set-up and calibration tasks, as well as performing rework and quality testing related to the production of parts, components and final materials. Additionally, the Manufacturing Technician uses sophisticated programs (such as LIMS, SAP, automated control systems, etc.) to collect and evaluate operating data, which can be used to conduct on-line adjustments to products, instruments or equipment. Lastly, the Manufacturing Technician determines and may assist in developing methods and procedures to control or modify the manufacturing process. Key Responsibilities Include: Shipping finished materials. Maintaining inventory levels. Sampling of in process and raw materials. Running...

Purpose The Product Quality Manager is responsible for providing quality assurance support for biologics manufacturing. This role will support areas concerning manufacturing, engineering, operations, logistics, quality control, training, and investigations with a focus on batch release. This position will furthermore support compliance and relevant regulatory requests in responsible manufacturing areas. Responsibilities Ensure proper integration and support of site, global, and health authority quality requirements, bulk drug substances and other application areas. Lead a quality team and provide guidance in cross function teams in the preparation, review, approval, and execution of quality documentation. Develop team training program to grow team skills and knowledge for emerging business models. Involvement in relevant investigations and associated CAPAs with a responsibility of approval and assurance of compliance, including integration with quality risk...

The distribution coordinator is responsible for warehouse lockdown scheduling for inbound & outbound deliveries, ensuring packaging and transport compliance with federal and international regulations . The coordinator maintains and reports department metrics and assumes responsibility for third party logistics cycle count activities and material return and disposal process. Additional responsibilities include collaboration to ensure inventory accuracy, cross functional communication, and forecasting to enable appropriate personnel allocation. The coordinator will monitor and procure supplies required for warehouse and shipping execution, initiative maintenance requests as needed and provide communication and coordination with the Maintenance management team.

The translational immunology team is seeking a highly motivated scientist with a strong background in immunology and autoimmunity, specifically in Systemic Lupus Erythematosus to advance the immunology pipeline. Our team is focusing on identifying new targets through computational analysis of human disease tissue derived datasets, and validation of targets using in vitro and in vivo experimental approaches. We are seeking a highly skilled and dedicated individual with Immunology laboratory experience both in vitro as well as in vivo. This position requires passion, attention to detail, hands-on experience, and teamwork. Key Responsibilities: Identification and validation of novel targets for the treatment of inflammatory conditions. Development of strategic plans to guide the selection and prioritization of identified targets. Generate proof of concept data supporting target Go/No Go decisions using in vitro and in vivo platforms. Experience with in vitro and/or in vivo...

As a Scientist I/II in the Multi-Specific Biologics Group, you will be responsible for the molecular cloning, production, and analysis of novel multi-specific biologics. A successful candidate will have experience in multiple facets of molecular biology and recombinant protein expression using mammalian and bacterial cell systems. Proficiency in protein purification and characterization utilizing laboratory automation is desired. The candidate must have a proven track record of delivering high quality experimental data. Experience with database tools for information management would also be desirable. In addition, the candidate must be able to demonstrate individual contributions to projects and to possess strong interpersonal skills. The scientist will be expected to represent the Multispecific Biologics group and present their data in project team meetings. Responsibilities Maintain a high level of productivity in the lab Independently design, execute, and interpret critical...

Cell and Protein Sciences (CPS) is seeking a highly motivated scientist to join the Protein Purification Group at the AbbVie Bioresearch Center in Worcester, MA. As a member of the group, the candidate will be responsible for the purification of antigens (native, recombinant, or stabilized forms) to advance the Discovery Biologics pipeline. The successful candidate will have experience in protein purification and analysis, excellent communication skills, and a collaborative mindset to effectively work with cross-functional groups. Key Responsibilities Include: Design and modify purification protocols to meet reagent requirements and deliverables Read and apply relevant scientific literature to improve protocols and understand project context Work with AKTA FPLC systems and Unicorn software to enable efficient processes Effectively communicate research progress through oral presentations and written documentation Keep accurate, detailed, and timely records of laboratory...

About AbbVie AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter , Facebook , Instagram , YouTube and LinkedIn . The Scientific IT group at AbbVie Bioresearch Center supports a variety of technical computing workloads serving a community of scientists focusing on pharmaceutical R&D. This position offers the opportunity to work in a cross functional team of informatics scientists and IT professionals in building a next generation scientific compute platform. We are looking for an exceptionally driven and hands-on Cloud...

The Precision Medicine Department is committed to advancing drug development and patient care through building a deeper understanding of disease biology and developing tools to optimize clinical decision making and customize treatment for patients. The Scientist will be part of a fast paced and multi-disciplinary team responsible for developing and implementing new technologies to enable decision making in clinical trials, and evaluate disease and drug biology. The successful candidate will have a demonstrated ability to design, execute, troubleshoot, and interpret experiments independently. The successful candidate will have expertise in advanced molecular techniques such as next generation sequencing and instrument automation. The successful candidate will also have experience with handling human tissues and samples, and developing assays to evaluate drug target engagement, receptor occupancy and pharmacodynamics, and interrogate disease and drug biology. Key Responsibilities:...

• Reviews daily production schedule and priorities to determine unit (suite) assignments and critical actions. • Reviews all materials and batch records required to support shift and any off-shift needs for the day. • Provides on the floor training to support formalized technical and cGMP training. Checks that operator training files match and support the processes they are required to carry out. • Monitors operator training files and works with compliance specialist to keep files up to date. • Works with QA and Subject Matter Expert (Tech Ops or Process Sciences) to resolve exceptions. • Works with technology transfer team to incorporate new processes in the plant. • Reviews new Batch records and SOPs. • Provides supervision primarily to skilled nonexempt and junior level exempt employees. Acts as advisor to unit or sub-unit, becomes actively involved as required. Acts as mentor for less senior personnel. • Evaluates staff performance.

We are seeking a highly motivated Associate Scientist/Engineer to join MSAT in the Operations S&T Biologics organization at AbbVie Bioresearch Center based in Worcester, MA. As part of the Operations S&T Biologics organization, our group leads the process technology transfer, optimization, validation, implementation, and continuous improvement for late-stage and commercial manufacturing of therapeutic proteins for AbbVie . We also provide technical support for manufacturing, GMP compliance, and regulatory filing. The candidate will work in a dynamic team environment to validate, implement process improvements, support and trouble shoot late clinical stage and commercial biologics manufacturing processes. A comprehensive understanding of protein chemistry and process scale-up is essential. Hands-on experience in the data trending and data analysis are required. Hands-on experience working in lab on process development is required. Good writing skills for technical reports...

Transfers methods into Production instructions to allow for successful performance of scheduled campaigns. Schedules work tasks, with general assistance, to support project and campaign timelines. Drafts moderate scope and complexity documents. Circulates documents to reviewers with general assistance, responds to comments and questions. Manages document review and approval to meet project timelines and provides status reports to management. Works with management and senior staff to determine appropriate course of action within defined procedures. Tracks ongoing problems and gathers information for analysis. Analyzes data to develop solutions to moderate-level problems. Applies knowledge, experience, and technical skills to understand ABC production objectives, to provide support to production initiatives, to execute procedures efficiently and compliantly, and use standard practices to ensure inter-group consistency. Works on problems of moderate complexity, where analysis...

The Scientific Informatics group at ABC supports R&D activities at the AbbVie Bioresearch Center that focuses on immunology and biologics therapeutic development. We are seeking a highly qualified S In this role, you will work collaboratively with technology and business groups to conceive, design and implement business technology solutions that solve significant scientific or business problems through the integration, visualization, and analysis of large and complex data. Investigate, identify, develop, and optimize methods, algorithms, and technologies to derive novel, competitive insights from disparate data sources or drive productivity and efficiency gains throughout multiple business areas. Contribute to advancement of technology in area of expertise. Develop productive collaborations and communications with other groups across multiple disciplines. The ideal candidate will be a technological jack of all trades who is intellectually curious, highly collaborative and...

We are seeking a highly motivated Scientist II/Senior Scientist I to join our Manufacturing Science and Technology (MSAT) group in the S&T Biologics at AbbVie Bioresearch Center based in Worcester, MA. As part of the S&T Biologics organization, our group leads the process technology transfer, optimization, validation, implementation, and continuous improvement for late-stage and commercial manufacturing of therapeutic proteins for AbbVie. We also provide technical support for manufacturing, GMP compliance, and regulatory filing. The candidate should have extensive experience and comprehensive knowledge in process development, characterization, validation and protein purification strategies to solve complex challenges across the AbbVie pipeline, including ADC. The candidate is expected to mentor and to supervise junior level scientists and productively manage several projects simultaneously in a dynamic and rapidly evolving project landscape. Key Responsibilities Include:...

An associate scientist I/II position is available within the Cell Culture group of the BioProcess Development Department at AbbVie Bioresearch Center in Worcester, MA. The group is responsible for developing and supporting cell culture manufacturing processes for early and late phase clinical programs. We strive for speedy delivery of quality processes that are high yield, amenable to efficient manufacturing operations, robust and provide desirable product quality attributes. The group interacts closely with other development groups, along with Manufacturing and Discovery. The selected candidate will be involved in cell culture media development, process development, process characterization, tech transfer and scale-up. We are seeking for an enthusiastic, creative scientist that can work independently and as part of a dynamic team environment. Key Responsibilities: Cultivate CHO cells in suspension at different bench-top scales (e.g. deep well plates, shake flasks, bioreactors)...

Performs more complex test methods as written to support product/material release with minimal error. Understands laboratory techniques and principles performed. Interprets experimental data for conformance with product/material specifications. Understands, implements and maintains GMP with respect to laboratory records, procedures, and systems in accordance with procedural requirements. Assists with writing and performs validation assays per approved protocols. Can effectively perform a multitude of laboratory techniques for which they are trained on with minimal error. Make recommendations for process improvement. Writes/revises procedures as necessary and provides support for department. Develops and maintains trend reports, backlog report, and document error reports which support departmental performance. Authors all types of Investigations and deviations effectively. Assist in troubleshooting assays.

Summary: The Information Research East organization at AbbVie supports pharmaceutical R&D scientists at our Worcester and Cambridge MA sites for their software and data analytics needs. This position offers the opportunity to work in a cross functional team of scientists and IT professionals solving challenging problems at the interface of software, lab hardware and IT infrastructure to drive the digital transformation of our laboratories. We are looking for an exceptional candidate with a background in scientific laboratory IT systems (LIMS, SDMS, CDS, etc) or lab instrument software. A successful candidate is one who can work in a fast-paced, cross-functional team to: 1) quickly diagnose and solve complex problems; 2) drive lab IT implementation projects including requirements gathering and testing; 3) help define strategies and operating models around information technology supporting scientific research. Key Responsibilities Include: Consults with scientific...