Associate Director, LNP Delivery Group Leader-Oligonucleotide Chemistry, RNA & Targeted Therapeutics - Brisbane, CA

  • Johnson & Johnson
  • Brisbane, CA, USA
  • Nov 14, 2022
Health Care

Job Description

Janssen R&D, a member of Johnson and Johnson's Family of Companies, is recruiting for an Associate Director, LNP Delivery Group Leader-Oligonucleotide Chemistry, RNA & Targeted Therapeutics within Therapeutics Discovery. This position will be based in Brisbane, CA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

RNA and Targeted Therapeutics is an organization within Therapeutics Discovery, committed to the delivery of high-quality drug candidates in the novel synthetic modalities space working closely with all six Janssen Therapeutic Areas (TA) discovery teams.

Our mission requires strategic thinking, portfolio mindset and deep scientific expertise in several disciplines including oligonucleotide chemistry, bioconjugation chemistry, nanotechnology, cellular and molecular pharmacology, and screening technologies coupled with an ability to work collaboratively with internal and external partners. We are currently seeking an outstanding individual to join our team as an Associate Director, LNP Delivery Group Leader - Oligonucleotide Chemistry, RNA & Targeted Therapeutics. This role offers tremendous growth opportunity within a dynamic and science-driven organization.

Key Responsibilities:
  • As a group leader, drive and direct the discovery of novel lipid nanoparticle (LNP) based delivery technology and platform to support RNA-based therapeutics and vaccine, working in concert with partners in molecular and cellular biology, pharmacology, computational chemistry, ADME, structural biology, chemical development, and other key functions.
  • Provide scientific direction, strategy and leadership for novel LNP discovery and formulation, process development, and optimization for in vivo delivery of mRNA, siRNA, gene therapy, and other therapeutic modalities.
  • Supervise and lead a group of scientists to design and execute the experiments to identify best-in-class LNP formulations to drive rapid advancement of RNA-LNP candidate selection.
  • Participate and contribute to discussions and projects with strategic external partners.
  • Supervise and manage third-party, CRO and CMOs for external collaboration and outsourced work as needed.
  • Critically evaluate experiment data and communicate scientific findings as verbal presentations and written reports; and provide updates on project status to Therapeutics Discovery leadership Team.

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