The Computational Biologist be part of an interdisciplinary research group combining systems biology, immunology, and human genetics to uncover the mechanisms that drive autoimmune disease. The lab leads large-scale efforts such as the VIGOR family-based vitiligo cohort (bigor.umassmed.edu) and multi-omic studies of lupus and cutaneous autoimmunity, integrating data across molecular, cellular, and clinical scales.
This position will bridge two complementary areas of research:
Molecular systems immunology, involving the analysis of single-cell and spatial transcriptomic, epigenomic, and proteomic datasets to dissect cell states and communication networks in diseased and healthy tissues.
Genetic and longitudinal modeling, integrating genomic variation with real-world longitudinal data-including proteomics, wearable device metrics, survey responses, and clinical measures-to build predictive and causal models of disease initiation and progression.The ideal candidate combines strong computational and statistical skills with a biological curiosity about how genetic and environmental factors jointly shape immune dysregulation.
